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D-Series

• Available For 25 mm Ports: Standard and Safety
• Fits Into the Fermenter / Bioreactor Side Port
• Dead Volume: Approximately 0.24 to 0.44 ml
• Used in PD to Production
• GMP Validated
• Immersion Depths: 90 and 115 mm
• 0.2 μm Membrane (Custom Pore Sizes Available)

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F-Series

• Available For 12 and 19 mm Ports
• Fits Into the Fermenter / Bioreactor Top Port
• Dead Volume: Approximately 0.24 to 0.44 ml
• Can Be Used With SUBs
• Compatible With Kleenpak™ Connectors
• Immersion Depths: 120, 200, 310, and 410 mm
• 0.2 μm Membrane (Custom Pore Sizes Available)

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Flownamics® has developed the FISP®, which is a sampling probe capable of withdrawing sterile, cell-free samples from fermentors and bioreactors. FISP® allows direct on-line sample transfer to a variety of analyzers, such as biochemistry and HPLC systems, as well as collection for off-line analysis. FISP® is a small, tube-shaped, sterilizable 316 stainless steel carrier which is surrounded by a tubular, micro-porous membrane.They are available for 12, 19 and 25 mm ports for use in laboratory, pilot or industrial scale vessels. FISP® has been and continues to be widely utilized in the fermentation and cell culture fields since it’s introduction to the market in 1996.

Features of the FISP®

• Sterile, Cell-Free Sampling for On-Line or Off-Line Analysis
• Autoclave, SIP, and CIP Compatible
• Risk Free Sampling with 0.2 Micron Filter (Sterile Barrier)
• Fits Small Laboratory to Large Full-Scale Production Vessels
• Collect and Store Samples for Off-Line Analysis
• Directly Interfaces the Fermentor or Bioreactor with:
 • Biochemistry Analyzers
 • Fraction Collectors, Autosamplers
 • Flow Injection Analysis (FIA) Systems
 • HPLC Systems
 • Biosensors
 • Methanol Analyzers
• Minimal Dead Volume for Consistent and Accurate Sampling, which Reduces Flush Time
• Withstands the Temperatures, Pressures, Viscosities, Shear Forces, and Chemicals Typical of Fermentation Environments
• Use with Aerobic or Anaerobic Bacteria, Yeast, Fungi, Algae, Insect, and Mammalian Cell Cultures
• Easy To Use and Maintain; No Operator Training Required
• Can Be Used for Submerged Feeding/Sterile Media Addition
Interfaces With Our Seg-Flow® Sampling System

Operation of the FISP®

The FISP is inserted into a side or top port of the vessel. It is immersed into the fermentation broth or culture media and sterilized in-situ. A peristaltic pump (or the vessel’s own hydrostatic pressure) withdraws a sample through the tubular membrane and into the probe’s stainless steel network of grooves. The sample flows through the network of grooves into a central channel where the cell-free sample can be directed to an on-line analyzer, fraction collector, or sample container. Fluid flow rate is dependent on the viscosity of the media.