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Bacterial Fermentation

  1. A streamlined strategy for biohydrogen production with Halanaerobium hydrogeniformans, an alkaliphilic bacterium. Begemann M., Mormile M., Sitton O., Wall J. and Elias D. 2012. Front. Microbio. 3:93. doi: 10.3389/fmicb.2012.00093
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325762/
  2. Comparison of polysialic acid production in Escherichia coli K1 during batch cultivation and fed-batch cultivation applying two different control strategies. Chen, R., John, J., Rode, B., Hitzmann, B., Gerardy-Schahn, R., Kasper, C., Scheper, T. Journal of Biotechnology. Volume 154, Issue 4, 20 July 2011, Pages 222-229.
    http://www.sciencedirect.com/science/article/pii/S0168165611002021
  3. High-level production of 1,3-propanediol from crude glycerol by Clostridium butyricum AKR102a. Wilkens, E., Ringel, A., Hortig, D., Willke, T., Vorlop, K. Applied Microbiology and Biotechnology. 2011 (online) p. 1-7.
    http://www.springerlink.com/content/f7xtl3h20x26837t/
  4. Quantitative analysis of isoprenoid diphosphate intermediates in recombinant and wild-type Escherichia coli strains. Vallon, T., Ghanegaonkar, S., Vielhauer, O., Müller, A., Albermann, C., Sprenger, G., Reuss, M. and Lemuth, K. Applied Microbiology and Biotechnology. 2008. Volume 81, Number 1, 175-182.
    http://www.springerlink.com/content/b774785211683715/
  5. Model based substrate set point control of yeast cultivation processes based on FIA measurements. Klockow, C., Hüll, D., Hitzmann, B. Analytica Chimica Acta. Vol. 623, Issue 1. August 2008, Pages 30–37.
    http://www.sciencedirect.com/science/article/pii/S0003267008011288
  6. Topology of the global regulatory network of carbon limitation in Escherichia coli. Hardiman, T., Lemuth, K., Keller, M., Reuss, M., Siemann-Herzberg, M. Journal of Biotechnology. Volume 132, Issue 4, 1 December 2007, Pages 359-374.
    http://www.sciencedirect.com/science/article/pii/S0168165607015210
  7. Preclinical Manufacture of an Anti-HER2 scFv-PEG-DSPE, Liposome-Inserting Conjugate. 1. Gram-Scale Production and Purification. Nellis, D. F., Ekstrom, D. L., Kirpotin, D. B., Zhu, J., Andersson, R., Broadt, T. L., Ouellette, T. F., Perkins, S. C., Roach, J. M., Drummond, D. C., Hong, K., Marks, J. D., Park, J. W. and Giardina, S. L. Biotechnology Progress. 2005. 21: 205–220.
    http://onlinelibrary.wiley.com/doi/10.1021/bp049840y/abstract

Yeast Fermentation

  1. Are Monod Models Enough for Bioreactor Control? Part1 – Experimental Results. Klockow, C., Hüll, D., Ferreira, L., Trierweiler, J., Hitzmann, B. 10th International IFAC Symposium on Computer Applications in Biotechnology. Preprints Vol. 1, June 4-6 2007. Cancun Mexico.
    http://www.nt.ntnu.no/users/skoge/prost/proceedings/dycops2007-and-cab2007/CAB/Monday/Posters/XPM09_62_Final_ManuscriptStampedno.pdf
  2. Modelling of Functional States during Saccharomyces cerevisiae Fed-batch Cultivation. Pencheva, T., Hristozov, I., Huell, D., Hitzmann, D., Tzonkov, S. Bioautomation. 2005, 2, 8-16.
    http://www.clbme.bas.bg/old_ba/2_1.2.pdf
  3. Implementation of Sliding Mode Controller with Boundary Layer for Saccharomyces cerevisiae Fed-batch Cultivation. Hristozov, I., Pencheva, T., Huell, D., Klockow, C., Hitzmann, B., Tzonkov, S. Bioautomation. 2005. 2, 49-53.
    http://www.biomed.bas.bg/bioautomation/2005/vol_2.1/files/2_2.3.pdf

Fungal Fermentation

  1. 1. Real-time analyte monitoring of a fungal fermentation, at pilot scale, using in situ mid-infrared spectroscopy. Pollard, D., Buccino, R., Connors, N., Kirschner, T., Olewinski, R., Saini, K., Salmon P. Bioprocess and Biosystems Engineering. 2001. Volume 24, No.1. 13 – 24.
    http://www.springerlink.com/content/w88x5byfmty700ey/

Mammalian Cell Culture

  1. Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures. Vallee, Cedric, Durocher, Yves, Henry, Olivier. Journal of Biotechnology. 2014. 169: 63-70.
    http://www.sciencedirect.com/science/article/pii/S0168165613004859
  2. Establishment of Higher Passage PER.C6 Cells for Adenovirus Manufacture. Berdichevsky, M., Gentile, M.-P., Hughes, B., Meis, P., Peltier, J., Blumentals, I., Auninš, J. and Altaras, N. E. Biotechnology Progress. 2008. 24: 158–165.
    http://onlinelibrary.wiley.com/doi/10.1021/bp070258u/full
  3. Metabolism of PER.C6TM cells cultivated under fed-batch conditions at low glucose and glutamine levels. Maranga, L. and Goochee, C. F. Biotechnology and Bioengineering. 2006. 94: 139–150.
    http://onlinelibrary.wiley.com/doi/10.1002/bit.20890/abstract
  4. Chemometric evaluation of on-line high-pressure liquid chromatography in mammalian cell cultures: Analysis of amino acids and glucose. Larson, T. M., Gawlitzek, M., Evans, H., Albers, U. and Cacia, J. 2002. Biotechnol. Bioeng., 77: 553–563. doi: 10.1002/bit.10116
    http://onlinelibrary.wiley.com/doi/10.1002/bit.10116/abstract
  5. Micro sequential injection: fermentation monitoring of ammonia, glycerol, glucose, and free iron using the novel lab-on-valve system. Chao-Hsiang Wu, Louis Scampavia, Jaromir Ruzicka and Bruce Zamost. Analyst. 2001. 126, 291-297.
    http://www.flowinjection.com/Brochures/LOVferm.pdf