Seg-Flow®

Automated Sampling System

The Seg-Flow® Automated On-line Sampling System provides multiple bioprocess monitoring and control solutions for improving process performance. The Seg-Flow® system’s patented Segmented On-line Sampling technology allows rapid and accurate sampling for 8 vessels or process streams and sample delivery to 4 analyzers and/or fraction collectors. Several feed control options are available with the Seg-Flow® system, which can control 2 pumps per vessel. Existing off-line and at-line analytics are seamlessly integrated into a multi-functional on-line PAT tool through the Seg-Flow® system’s communication interface and FlowWeb™ control software. The FlowWeb™ software simultaneously acquires all integrated instrument data and can export the data to any OPC-enabled SCADA for enhanced process monitoring and control.

The new generation of the Flownamics® automated sampling system, the Seg-Flow S3® product line, is characterized by robust hardware, the intuitive handling of hoses with intelligent pinch valves and non-contact ultrasonic sensors. A series of LED status lights indicate the phases of sampling and the sequence of cleaning, rinsing, sampling, air, idling and the end of the process.

The new user interface offers intuitive menus with more planning options and reagent status information. The optional Sample-Mod S3® module is used for sample pre-dilution in selectable steps up to 1:10, can automatically add reagents to the native sample and distributes the sample to up to four analysis or filling systems. The cleaning and disinfection of the flow channel takes place from the central Reagent-Mod S3® module. The cooled filling station models FlowFraction 400 fill the sample into sample vessels, e.g. 15 ml centrifuge tubes

Image of the Seg-Flow S3 automated sampling system with technical information bulletins.

Seg-Flow S3® Automated On-Line Sampling System

Introducing the new generation of the Flownamics® automated sampling system, the SegFlow S3®. This product line is characterized by robust hardware, the intuitive handling of hoses with intelligent pinch valves and non-contact ultrasonic sensors. A series of LED status lights indicate the phases of sampling and the sequence of cleaning.

The new user interface offers intuitive menus with more planning options and reagent status information. The optional Sample-Mod S3® module is used for sample pre-dilution in selectable steps up to 1:10, can automatically add reagents to the native sample and distributes the sample to up to four analysis or filling systems. The cleaning and disinfection of the flow channel takes place from the central Reagent-Mod S3® module. The cooled filling station models FlowFraction 400 fill the sample into sample vessels, e.g. 15 ml centrifuge tubes. 

The Seg-Flow S3® Automated Sampling System has many Benefits

  • Reduces the workload of lab personnel by automatically taking samples – even at night and weekends 
  • Controls data flow 
  • Reduces variability of sampling 
  • Cuts down on potential contamination of samples 
  • Provides easier data management 

All of the Great Qualities of Our Previous Systems, but with New Features

  • Redesigned chassis to improve ease of use and aesthetics 
  • Built-in Reagent Module allows the sampling of 8 vessels right out of the box and saves room on the bench top 
  • New LED lights will change color to match status as the Seg-Flow S3® moves through the sampling cycle 
  • New built-in tubing management channels make tube installation easy and quick and ensures tubing stays in place 
  • New Graphical User Interface makes the S3 monitoring more intuitive and easy to track progress of the sampling cycle 
  • Improved peristaltic pump 
  • Ultrasonic sensors and self-testing pinch valves alerts Users if there is a blocked or misconnected tube 
  • New Seg-Mod S3 is designed specifically for the Seg-Flow S3® and also include improved tubing management 

Seg-Flow S3® Videos

  • Rapid and accurate sampling
  • Sample from 1-8 vessels/process streams
  • Deliver samples to 4 analyzers/fraction collectors
  • Withdraw cell-free or cell-containing samples
  • On-line monitoring of nutrients, metabolites and cell growth
  • Sample line is cleaned and/or sterilized after every sample

Flownamics® partners with many of the top manufactures of analytical instrumentation in the biotechnology and bioprocess industries. These partnerships provide us with robust and seamless integrations to many platforms. We can also create custom system integrations for systems not listed on our website. Contact us to discuss your system integration. 

  • Control 2 feed pumps per vessel
  • Setpoint control, gravimetric feed control
  • Other feed algorithms can be programmed
  • Pump interfaces include: Watson-Marlow, Cole-Parmer®, MasterFlex®, SciLog® ACCU Digital, and Ivek.
  • Other pump interfaces available upon request

  • Sartorius BioPAT® MFCS
  • DASGIP DASware
  • Eppendorf BioCommand®
  • Broadley-James BioNet®
  • Emerson Delta V

Dimensions

  • Width: 31.75 cm (12.5 in)
  • Height: 50.8 cm (20 in)
  • Depth: 35.6 cm (14.0 in)

Weight

  • 10.52 kg (23.2 lbs)

Electrical

  • External Power Supply: Auto-sensing: 100-120 VAC / 220 – 240 VAC, 1.5 A (50/60 Hz)
  • Power Consumption: 150 VA
  • System Requirements: 15 VDC, 10 A
  • Regulatory Compliance: CE, RoHS

System Control

  • Software: FlowWeb™ web-based software controlled by internal processor
  • OPC Data Exchange: Optional OPC server package available

Contact us for more information about our previous Seg-Flow models. 

Product image of the Seg-Flow 4800, a previous generation of Seg-Flow Automated Sampling System.

Seg-Flow 4800®