Bacterial Fermentations

Multivariate curve resolution and carbon balance constraint to unravel FTIR spectra from fed-batch fermentation samples. Vier D, Wambach S, Schünemann V, and K-U Gollmer. Bioengineering (2017) 4(1):9.

A streamlined strategy for biohydrogen production with Halanaerobium hydrogeniformans, an alkaliphilic bacterium. Begemann M, Mormile M, Sitton O, Wall J, and D Elias. Frontiers in Microbiology (2012) 3:93.

Comparison of polysialic acid production in Escherichia coli K1 during batch cultivation and fed-batch cultivation applying two different control strategies. Chen R, John J, Rode B, Hitzmann B, Gerardy-Schahn R, Kasper C, and T Scheper. Journal of Biotechnology (2011) 154(4):222-229.

High-level production of 1,3-propanediol from crude glycerol by Clostridium butyricum AKR102a. Wilkens E, Ringel A, Hortig D, Willke T, and K Vorlop. Applied Microbiology and Biotechnology (2011) p. 1-7.

Quantitative analysis of isoprenoid diphosphate intermediates in recombinant and wild-type Escherichia coli strains. Vallon T, Ghanegaonkar S, Vielhauer O, Müller A, Albermann C, Sprenger G, Reuss M, and K Lemuth. Applied Microbiology and Biotechnology (2008) 81(1):175-182.

Model based substrate set point control of yeast cultivation processes based on FIA measurements. Klockow C, Hüll D, and B Hitzmann. Analytica Chimica Acta (2008) 623(1):30-37.

Topology of the global regulatory network of carbon limitation in Escherichia coli. Hardiman T, Lemuth K, Keller M, Reuss M, and M Siemann-Herzberg. Journal of Biotechnology (2007) 132(4):359-374.

Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. Nellis DF, Ekstrom DL, Kirpotin DB, Zhu J, Andersson R, Broadt TL, Ouellette TF, Perkins SC, Roach JM, Drummond DC, Hong K, Marks JD, Park JW, and SL Giardina. Biotechnology Progress (2005) 21:205-220.

Fungal Fermentations

High-oleate yeast oil without polyunsaturated fatty acids. Tsakraklides V, Kamineni A, Consiglio AL, MacEwen K, Friedlander J, Blitzblau HG, Hamilton MA, Crabtree DV, Su A, Afshar J, Sullivan JE, LaTouf WG, South CR, Greenhagen EH, Shaw AJ, and EE Brevnova. Biotechnology for Biofuels (2017) 11:32.

Enhanced lipid production by Rhodosporidium toruloides using different fed-batch feeding strategies with lignocellulosic hydrolysate as the sole carbon source. Fei1 Q, O’Brien M, Nelson R, Chen X, Lowell A, and N Dowe. Biotechnology for Biofuels (2016) 9:130.

Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels. LiVivian X, YuYuping Y, Lin Y, Chomvong K, Chomvong K, Estrela R, Park A, Liang JM, Znameroski EA, Feehan J, Kim SR, Jin Y-S, Glass NL, and JHD Cate. Bioprocess and Biosystems Engineering (2015) 24(1):13-24.

Real-time analyte monitoring of a fungal fermentation, at pilot scale, using in situ mid-infrared spectroscopy. Pollard D, Buccino R, Connors N, Kirschner T, Olewinski R, Saini K, and P Salmon. Bioprocess and Biosystems Engineering (2001) 24(1):13-24.

Mammalian Cell Culture

Online flow cytometry for monitoring apoptosis in mammalian cell cultures as an application for process analytical technology. Kuystermans D, Avesh M, and M Al-Rubeai. Cytotechnology (2016) 68(3):399-408.

Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures. Vallee C, Durocher Y, and H Olivier. Journal of Biotechnology, (2014) 169: 63-70.

Establishment of higher passage PER.C6 cells for Adenovirus manufacture. Berdichevsky M, Gentile M-P, Hughes B, Meis P, Peltier J, Blumentals I, Auninš J, and NE Altaras. Biotechnology Progress (2008) 24:158-165.

Metabolism of PER.C6TM cells cultivated under fed-batch conditions at low glucose and glutamine levels. Maranga L and CF Goochee. Biotechnology and Bioengineering (2006) 94:139-150.

Chemometric evaluation of on-line high-pressure liquid chromatography in mammalian cell cultures: Analysis of amino acids and glucose. Larson TM, Gawlitzek M, Evans H, Albers U, and J Cacia. Biotechnology and Bioengineering (2002) 77:553-563.

Micro sequential injection: fermentation monitoring of ammonia, glycerol, glucose, and free iron using the novel lab-on-valve system. Wu C-H, Scampavia L, Ruzicka J, and B Zamost. Analyst (2001) 126:291-297.

Yeast Fermentation

Are monod models enough for bioreactor control? Part 1-Experimental Results. Klockow C, Hüll D, Ferreira L, Trierweiler J, and B Hitzmann. 10th International IFAC Symposium on Computer Applications in Biotechnology (2007).

Modelling of functional states during Saccharomyces cerevisiae fed-batch cultivation. Pencheva T, Hristozov I, Huell D, Hitzmann D, and S Tzonkov. Bioautomation (2005) 2:8-16.

Implementation of sliding mode controller with boundary layer for Saccharomyces cerevisiae fed-batch cultivation. Hristozov I, Pencheva T, Huell D, Klockow C, Hitzmann B, and S Tzonkov. Bioautomation (2005) 2:49-53.

Other Publications

Industrializing autologous adoptive immunotherapies: Manufacturing advances and challenges. Iyer RK, Bowles PA, Kim H, and A Dulgar-Tulloch. Frontiers in Medicine (2018) 5:150.

On-demand manufacturing of clinical-quality biopharmaceuticals. Crowell LE, Lu AE, Love KR, Stockdale A, Timmick SM, Wu D, Wang YA, Doherty W, Bonnyman A, Vecchiarello N, Goodwine C, Bradbury L, Brady JR, Clark JJ, Colant NA, Cvetkovic A, Dalvie NC, Liu D, Liu Y, Mascarenhas CA, Matthews CB, Mozdzierz NJ, Shah KA, Wu SL, Hancock WS, Braatz RD, Cramer SM, and JC Love. Nature Biotechnology (2018) 36(10):988-99.

Opportunities and challenges of real‐time release testing in biopharmaceutical manufacturing. Jiang M, Severson KA, Love JC, Madden H, Swann P, Zang L, and RD Braatz. Biotechnology and Bioengineering (2017) 114(11):2445-2456.

Rapid bioprocess culture characterization: system designed to enable real-time monitoring of microbial cultures. Blattner C, Blattner FR, Biksacky M and W Miller. Genetic Engineering and Biotechnology News (2015) 35(5).

Ex situ online monitoring: application, challenges, and opportunities for biopharmaceuticals processes. Fei1 Q, O’Brien M, Nelson R, Chen X, Lowell A, and N Dowe N. Pharmaceutical Bioprocessing (2014) 2(3):285-300.